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Indazole

CAS No. : 271-44-3

MCE 国际站：Indazole

产品活性：吲哚唑，又称异吲哚唑 (isoindazole)，是一种杂环芳香有机化合物。其衍生物表现出广泛的生物活性，包括抗炎、抗菌、抗艾滋病、抗心律失常、抗真菌和抗肿瘤的特性。吲哚唑及其衍生物可用于癌症、神经系统疾病、心血管疾病、胃肠道疾病的研究。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt  |  PI3K/Akt/mTOR  |  Autophagy

作用靶点：Monoamine Oxidase  |  GSK-3  |  LRRK2

In Vitro: Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents.
Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2).
Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders.

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