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BLU-945

CAS No. : 2660250-10-0

MCE 国际站：BLU-945

产品活性：BLU-945 是一种强效、高选择性、可逆的表皮生长因子受体酪氨酸激酶抑制剂 (TKIs)，具有口服活性。BLU-945 可有效抑制具有 L858R 和/或外显子 19 缺失突变、T790M 突变和 C797S 突变的 EGFR。BLU-945 可用于肺癌包括非小细胞肺癌（NSCLC）的研究。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：EGFR

In Vitro: BLU-945 has inhibitory activity against the EGFRm/T790M double and EGFRm/T790M/C797Striple mutants with IC₅₀ value range from 1.2-4.4 nM.
BLU-945 (0- 10 mM, 4 h) inhibit EGFR phosphorylation in the EGFR L858R/T790M/C797S, and EGFR ex19del/T790M/C797S mutant cell lines.

In Vivo: BLU-945 (oral, 0-100 mg/kg; bid) demonstrates potent, robust EGFR pathway inhibition and anti-tumor activity in triple-mutant Osimertinib (HY-15772)-resistant Ba/F3 CDX and PDCX models.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Orally Active Compound Library  |  Anti-Hepatitis C Virus Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  EGFR/HER2/CDK9-IN-2  |  Lapatinib ditosylate  |  BMS-690514  |  Erlotinib-d₆ hydrochloride  |  EGFR/CDK2-IN-1  |  JBJ-04-125-02  |  EGFR-IN-22  |  EGFR-IN-34  |  Epertinib  |  Ponezumab  |  Erlotinib Hydrochloride  |  EGFR-IN-36  |  EGFR-IN-62  |  Genistein  |  Panitumumab (anti-EGFR)  |  Lirafugratinib  |  Lapatinib-d₇ dihydrochloride  |  (E/Z)-CP-724714  |  TAS0728  |  Rezivertinib  |  Tucatinib hemiethanolate  |  Osimertinib mesylate  |  AV-412 free base  |  Falnidamol  |  EGFR/ErbB-2/ErbB-4 inhibitor-2  |  Trastuzumab  |  EGFR-IN-58  |  Naquotinib  |  MS9449

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