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CAS No. : 4430-36-8
MCE 国际站:Erucin
产品活性:Erucin (ERU) 是一种异硫氰酸盐 (isothiocyanate),在芝麻菜 (arugula) 中尤其丰富。Erucin 具有抗癌、神经保护和抗炎活性。
研究领域:Apoptosis
作用靶点:Apoptosis
In Vitro: Erucin (ERU) (0-100 μM) releases H2S and inhibits cell viability in AsPC‐1 cells in a concentration-dependent manner.
Erucin inhibits cell migration and altered the AsPC‐1 cell cycle, reducing G0/G1 phase and increasing G2/M and S phases.
Erucin (30 μM, 72 h) induces AsPC‐1 cell apoptosis and inhibits cell migration.
Erucin reduces levels of phosphorylated ERK1/2 in AsPC‐1 cells.
Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC50 of 97.7 µM in A549 cells.
Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 µM, and increases p53 and p21 protein expression in A549 cells.
Erucin decreases LPS-induced production of NO, prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-1β in RAW 264.7 cells.
Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in RAW 264.7 cells.
Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells.
In Vivo: Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation.
Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects.
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