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CAS No. : 2761004-85-5
MCE 国际站:GPX4-IN-3
产品活性:GPX4-IN-3 (26a) 是有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂,可选择性诱导铁死亡 (ferroptosis)。GPX4-IN-3 (26a) 在1 μM 的浓度可抑制GPX4 71.7% 活性。
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Glutathione Peroxidase | Ferroptosis
In Vitro: GPX4-IN-3 (26a) exhibits IC50 values of 0.78 μM, 6.9 μM, 0.15 μM and 4.73 μM in 4T1, MCF-7, HT1080 and HT1080 (with Fer-1) cells, respectively.
GPX4-IN-3 (26a) exhibits outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3.
GPX4-IN-3 (26a) could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity.
GPX4-IN-3 (26a) is more likely to induce ferroptosis through the accumulation of intracellular peroxides via inhibiting GPX4 activity.
GPX4-IN-3 (26a) significantly increased the level of ROS in 4T1 cells, which could also be reversed by Ferrostatin-1 (fer-1).
In Vivo: GPX4-IN-3 (26a) exertes antitumor activity and good biological safety in vivo.
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Anti-Cancer Metabolism Compound Library | Cuproptosis Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Sorafenib-d4 | Lapatinib ditosylate | Ciclopirox olamine | Curcumin | L-Glutamine-d5 | HDAC-IN-48 | (S)-L-Cystine-15N2 | L-Glutamine-13C5,15N2 | Lapatinib-d7 dihydrochloride | Sorafenib Tosylate | Deferiprone | Verdiperstat | Cycloheximide | Pravastatin sodium | YL-939 | (-)-Epicatechin | Dopamine-d5 hydrochloride | Linagliptin-d4 | Acetylcysteine-d3 | Dopamine hydrochloride | (E)-Ferulic acid | AZD5904 | PD146176 | Pifithrin-β hydrobromide | Pseudolaric Acid B | L-Glutamic acid-d5 | Roxadustat | Matrine | Liproxstatin-1
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货号: HY-141809
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