MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 145757-47-7
MCE 国际站:Carboxy-PTIO
产品活性:Carboxy-PTIO 是一种有效的一氧化氮 (NO) 清除剂,能与 NO 快速反应产生 NO2。Carboxy-PTIO 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用,可预防低血压和内毒素休克。
研究领域:Immunology/Inflammation
作用靶点:NO Synthase
In Vitro: Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells.
In Vivo: Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.
相关产品:Palmitoylglycine | Ermanin | Cistanoside A | Isophysalin A | Mifepristone-13C,d3 | Dehydroevodiamine hydrochloride | Chondroitin sulfate | N'-Nitro-D-arginine | Banoxantrone | Crocin II | L-NIL hydrochloride | L-Arginine-d7 hydrochloride | Ethyl 3,4-dihydroxybenzoate | (+)-Hannokinol | 2-Thiouracil-13C,15N2 | NOS-IN-3 | Morachalcone A | 3-Bromo-7-nitroindazole | Ethyl Caffeate | Beclometasone dipropionate | Carboxyebselen | (-)-10,11-Dihydroxyfarnesol | Cauloside C | Mifepristone-d3 | Randaiol | Atraric acid | Chloranthalactone E | Dimaprit dihydrochloride | Britannilactone diacetate | 2-Iminobiotin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-18734
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。