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CAS No. : 2090064-66-5
MCE 国际站:Vebicorvir
产品活性:Vebicorvir (ABI-H0731) 是一代乙型肝炎病毒 (HBV) 核心蛋白的抑制剂。Vebicorvir (ABI-H0731) 共价抑制两个感染模型中cccDNA 的 EC50 值为 1.84-7.3 μM。
研究领域:Anti-infection
作用靶点:HBV
In Vitro: Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68 μM, 4.95 μM, and 7.30 μM, respectively.
Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis.
In Vivo: After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively.
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货号: HY-109195
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