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CAS No. : 1781835-13-9
MCE 国际站:RN-1 dihydrochloride
产品活性:RN-1 dihydrochloride 是一种有效的、可透过血脑屏障、不可逆的、选择性的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,IC50 为 70 nM。RN-1 dihydrochloride 对 LSD1 的选择性高于 MAO-A 和 MAO-B,IC50 值分别为 0.51 μM 和 2.785 μM。
研究领域:Epigenetics
作用靶点:Histone Demethylase
In Vitro: RN-1 dihydrochloride shows cytotoxic for ovarian cancer cells (SKOV3, OVCAR3, A2780 and cisplatin-resistant A2780cis), with IC50 values of ≈100-200 μM.
In Vivo: RN-1 (3-10 mg/kg; i.p.; daily; for 2 or 4 consecutive weeks) dihydrochloride effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology in SCD mice.
In C57BL/6 male mice, after intraperitoneal administration of RN-1 dihydrochloride (10 mg/kg), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. The brain/plasma exposure ratio is 88.9. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory.
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