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CAS No. : 2754265-25-1
MCE 国际站:TNIK-IN-3
产品活性:TNIK-IN-3 (化合物 21k) 是一种有效,选择性和具有口服活性的 TNIK 抑制剂,IC50 值为 0.026 μM。TNIK-IN-3 还可以抑制 Flt4 (IC50=0.030 μM),Flt1 (IC50=0.191 μM) 和 DRAK1 (IC50=0.411 μM)。TNIK-IN-3 可用于结直肠癌的研究。
研究领域:Apoptosis
作用靶点:DAPK
In Vitro: TNIK-IN-3 (compound 21k) inhibits Aurora-A, GCK, and MLK3 with IC50s of 0.517 μM, 3.657 μM, and 4.552 μM, respectively.
TNIK-IN-3 (0.1-100 μM; 3 days) inhibits the viability of HCT116 and DLD-1 cells, with IC50s of 4.26 μM and 8.00 μM, respectively.
TNIK-IN-3 (2.5-40 μM; 10 days) dose-dependently inhibits the colony formation of HCT116 and DLD-1 cells.
TNIK-IN-3 (5-20 μM; 48 h) inhibits the migration of HCT116 and DLD-1 cells.
TNIK-IN-3 (5-40 μM; 48 h) dose-dependently inhibits the expression ofLRP5 and LRP6 proteins, Wnt target genes AXIN2 and c-Myc in HCT116 cells.
TNIK-IN-3 (5-20 μM; 48 h) significantly suppresses the phosphorylation of JNK1/2 in Hela cells.
In Vivo: TNIK-IN-3 (compound 21k) (100-150 mg/kg; p.o. twice daily for 18 days) inhibits tumor growth in a dose-dependent manner.
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Orally Active Compound Library | Anti-Colorectal Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | DAPK Substrate Peptide TFA | CK156 | HS56 | TC-DAPK 6 | DRAK2-IN-1 | DRAK1/2-IN-1 | TAT-GluN2BCTM | HS38 | 3MB-PP1
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-145293
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