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CAS No. : 1185329-96-7
MCE 国际站:IXA4
产品活性:IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂。IXA4 激活IRE1/XBP1s 信号,而没有全局激活未折叠蛋白反应 (UPR) 或其他应激反应信号通路 (例如热休克反应或氧化应激反应)。IXA4 通过激活 IRE1 减少 APP 分泌。
研究领域:Cell Cycle/DNA Damage
作用靶点:IRE1
In Vitro: IXA4 (10 μM; 4 hours) selectively upregulates XBP1s mRNA, relative to genes regulated by ATF6 (e.g., BiP) or PERK (e.g., CHOP), in other cell lines including Huh7 and SHSY5Y cells.
IXA4 (10μM; 18 hours) reduces Aβ levels 50% in conditioned media prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant.
IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-relevant APP mutants. IXA4 (10μM; 4 hours) promotes adaptive IRE1/XBP1s signaling, but not RIDD, following 4 hrs of treatment in HEK293T cells.
IXA4 also promotes selective transcriptional remodeling of ER proteostasis pathways, relative to cytosolic or mitochondrial pathways.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Oxygen Sensing Compound Library | Endoplasmic Reticulum Stress Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Toyocamycin | IRE1α kinase-IN-4 | 4μ8C | 3,6-DMAD hydrochloride | GSK2850163 (S enantiomer) | KIRA9 | IRE1α kinase-IN-6 | B I09 | Sunitinib | IRE1α kinase-IN-7 | KIRA6 | IXA6 | MKC3946 | IRE1α kinase-IN-1 | IRE1α kinase-IN-3 | MKC9989 | Kira8 Hydrochloride | 6-Bromo-2-hydroxy-3-methoxybenzaldehyde | MKC8866 | Z4P | IRE1α kinase-IN-5 | GSK2850163 hydrochloride | IRE1α kinase-IN-8 | STF-083010
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