MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

R 59-022 hydrochloride

CAS No. : 93076-98-3

MCE 国际站：R 59-022 hydrochloride

产品活性：R 59-022 (DKGI-I) hydrochloride 是一种 DGK 抑制剂 (IC₅₀: 2.8 µM)。R 59-022 hydrochloride 抑制 OAG 磷酸化为 OAPA。R 59-022 hydrochloride 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。

研究领域：Epigenetics  |  TGF-beta/Smad  |  GPCR/G Protein  |  Neuronal Signaling

作用靶点：PKC  |  5-HT Receptor

In Vitro: R 59-022 (10 μM, 1 min) hydrochloride potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin.
R 59-022 (30 μM, 0-60 min) hydrochloride increases release of Noradrenaline in chromaffin cells.
R 59-022 (40 μM, 30 min) hydrochloride activates PKC in HeLa and U87 cells.
R 59-022 (0-10 μM, 4 h) hydrochloride blocks EBOV GP-mediated entry into Vero cells.

In Vivo: R 59-022 (2 mg/kg, i.p., 12 days) hydrochloride significantly increases median survival in SCID mice implanted with U87 GBM cells.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Epigenetics Compound Library  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Cytoskeleton Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  5-HT Receptor Compound Library  |  Coagulation and Anti-coagulation Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  SB 243213  |  Perphenazine-d₈ dihydrochloride  |  (Rac)-SEP-363856  |  Bromperidol-d₄-1  |  SB-218078  |  Loxapine-d₈ hydrochloride  |  ARC 239  |  p32 Inhibitor M36  |  Ondansetron-d₃  |  Zotepine  |  Staurosporine  |  Paliperidone-d₄  |  N-Myristoyl-Lys-Arg-Thr-Leu-Arg  |  Dehydroaripiprazole  |  Nuciferine  |  PF-04577806  |  Ziprasidone hydrochloride monohydrate  |  Bisindolylmaleimide II  |  WAY-100635 Maleate  |  Velusetrag  |  Hypericin  |  (S)-Mirtazapine  |  Eletriptan  |  Pindolol-d₇  |  Paliperidone palmitate  |  p-MPPI hydrochloride  |  LY 344864 racemate  |  Paliperidone  |  LY-272015 hydrochloride  |  D-erythro-Sphingosine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-107613A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。