MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 53179-07-0
MCE 国际站:Nisoxetine
产品活性:Nisoxetine 是一种有效的和选择性的去甲肾上腺素转运蛋白 (NET) 抑制剂,Kd 值为 0.76 nM。Nisoxetine 是一种抗抑郁试剂和局部麻药,它可以阻断电压门控性钠通道。
研究领域:Membrane Transporter/Ion Channel
作用靶点:Monoamine Transporter | Sodium Channel
In Vitro: Nisoxetine inhibits [3H]Nisoxetine binding to rat frontal cortical membranes with a Ki of 1.4±0.1 nM.
Nisoxetine inhibits [3H]Noradrenaline uptake into rat frontal cortical synaptosomes with a Ki of 2.1±0.3 nM.
Nisoxetine inhibits Na+ currents with IC50s of 1.6 and 28.6 µM at the membrane potential of -70 and -100 mV, respectively.
In Vivo: Nisoxetine (2.2 µM; a single intrathecal injection) shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively.
Nisoxetine (3,10, 30 mg/kg, i.p.) inhibits refeeding response (intake of standard chow) in rats.
相关产品:Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuroprotective Compound Library | Mechanoreceptors Compound Library | Antidepressant Compound Library | Sodium Channel Blocker Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | RY785 | Ropivacaine hydrochloride | GMQ | Ranolazine-d8 dihydrochloride | F15845 | Licarbazepine | NaV1.2/1.6 channel blocker-1 | Propafenone-d5 hydrochloride | Carbamazepine-d2 | Funapide | Dibucaine | VGSC blocker-1 | Pilsicainide | BI 01383298 | Disopyramide | 20(S)-Ginsenoside Rg3 | Benzocaine-d4 | (Rac)-Ropivacaine-d7 | Methocarbamol | β-Pompilidotoxin | Tetrabenazine Racemate | Oxcarbazepine-d4-1 | Fluphenazine dimaleate | Eslicarbazepine acetate | Ranolazine-d5 | Ropivacaine mesylate | Zandatrigine | Mebeverine hydrochloride | ICA-121431 | Brompheniramine maleate
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-B1704
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。