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CAS No. : 452342-37-9
MCE 国际站:GW-6604
产品活性:GW-6604 是一种 ALK5 抑制剂,抑制其自磷酸化的 IC50 值为140 nM,可用于肝纤维化疾病研究。
研究领域:TGF-beta/Smad
作用靶点:TGF-β Receptor
In Vitro: GW-6604 (0-10 μM, ) inhibits TGF-β-induced PAI-1 transcription and secretion in HepG2 cells with an IC50 value of 500 nM, effectively blocking the Smad-dependent response[1].
In Vivo: GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks) dependently inhibits hepatic COL IA1 overexpression in an acute DMN model in SD rats, reducing its expression by 80%. Normal liver weight was maintained, liver fibrosis was effectively reduced and matrix degeneration was increased.
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货号: HY-10327
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