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CAS No. : 908112-37-8
MCE 国际站:AT-533
产品活性:AT-533 是一种有效的 Hsp90 和 HSV 抑制剂。AT-533 通过阻断 HIF-1α/VEGF/VEGFR-2 信号通路抑制肿瘤生长和血管生成。AT-533 还抑制下游通路的激活,包括 Akt/mTOR/p70S6K, Erk1/2 和 FAK。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的管形成、细胞迁移和侵袭。
研究领域:Cell Cycle/DNA Damage | Metabolic Enzyme/Protease | Anti-infection | Protein Tyrosine Kinase/RTK | NF-κB | MAPK/ERK Pathway | Stem Cell/Wnt | PI3K/Akt/mTOR
作用靶点:HSP | HSV | HIF/HIF Prolyl-Hydroxylase | VEGFR | NF-κB | ERK | Akt | FAK
In Vitro: AT-533 (0-1350 nM; 24 h or 48 h) inhibits 20 ng/mL VEGF-induced tube formation, cell migration, and invasion of HUVECs.
AT-533 (2 μM or 75 μM; 24 h) inhibits the HIF-1α/VEGF signaling pathway in hypoxia-induced breast cancer cells, as well as inhibiting Akt/mTOR/p70S6K, Erk1/2, and FAK phosphorylation.
AT-533 (10 nM, 50 nM; 48 h) shows anti-angiogenic ability in chorioallantoic membrane (CAM) model.
AT-533 (0.5 μM; 2 h, 4 h) decreases TNF-α, IL-1β and IL-6 production in RAW264.7 and BV2 cells induced by HSV-1.
In Vivo: AT-533 (10 mg/kg; i.p.; once daily for 21 d) suppresses the expression of the HIF-1α/VEGF signaling pathway-related proteins in MDA-MB-231 breast cancer xenografts tumor model in mouse.
AT-533 (1, 2 and 4 mg/kg; i.p.; once daily for 30 d) has no mortality, loss of appetite and body weight, adverse reactions in Sprague-Dawley rats in subacute toxicity test.
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货号: HY-148877
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