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CAS No. : 1917306-14-9
MCE 国际站:JNJ-61803534
产品活性:JNJ-61803534 是一种有效的、具有口服活性 RORγt 反向激动剂,IC50 为 9.6 nM。JNJ-61803534 具有抗炎活性。JNJ-61803534 在 Th17 分化条件下抑制人 CD4+ T 细胞产生 IL-17A。
研究领域:Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor
作用靶点:ROR
In Vitro: JNJ-61803534 inhibits RORγt transcription in HEK-293 T cells transfected with vectors encoding RORγt, with an IC50 of 9.6 nM.
JNJ-61803534 (1 nM-1 μM) inhibits IL-17A, IL-17F IFNγ and IL-22 production in CD4+ T cells isolated from human blood.
JNJ-61803534 does not impact in vitro Treg differentiation in CD4+ T cells.
In Vivo: JNJ-61803534 (100 mg/kg, p.o.) inhibits ex vivo stimulated IL-17A production in the blood of mice.
JNJ-61803534 (3-100 mg/kg BID or 60 mg/kg QD, p.o.) alleviates inflammation, cartilage damage, bone destruction in mouse collagen-induced arthritis (CIA) model.
JNJ-61803534 (30 and 100 mg/kg, p.o.) alleviates Imiquimod (HY-B0180)-induced dermal psoriatic-like inflammation in mice.
相关产品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Clinical Compound Library | Small Molecule Immuno-Oncology Compound Library | Orally Active Compound Library | Transcription Factor-Targeted Library | Antidepressant Compound Library | Nuclear Receptor Compound Library | SR3335 | Methyl-3β-hydroxycholenate | Bevurogant | PF-06747711 | Zilovertamab | XY101 | RORγt inhibitor 2 | RORγt Inverse agonist 8 | RORγt agonist 3 | RORγt modulator 2 | SR0987 | AZD-0284 | RORγt Inverse agonist 6 | ARN-6039 | RORγ agonist 1 | RORγt/DHODH-IN-2 | SR1001 | 3-Oxo-5β-cholanoic acid | GNE-6468 | RORγt inverse agonist 29 | 7ß,27-Dihydroxycholesterol | Nobiletin | CD12681 | BMS-986251 | TAK-828F | RORγt inverse agonist 13 | RORγt Inverse agonist 3 | SHR168442 | GSK805 | SR1555
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货号: HY-139780
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