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Voxvoganan trihydrochloride

CAS No. :

MCE 国际站：Voxvoganan trihydrochloride

产品活性：Voxvoganan (LTX-109) trihydrochloride 是一种局部抗菌剂 (antimicrobial)，对 S. aureus 非常有效，MIC为2-4 μg/mL。Voxvoganan trihydrochloride 可用于细菌性皮肤感染、真菌感染的研究。

研究领域：Anti-infection

作用靶点：Fungal  |  Bacterial

In Vitro: Voxvoganan trihydrochloride (LTX-109) is an investigational antimicrobial agent with a membrane-lysing mechanism of action, based on the biological principle of innate immune effectors, lytic peptides. Voxvoganan trihydrochloride has a rapid bactericidal lytic activity. Voxvoganan trihydrochloride demonstrates in vitro bactericidal activity against a number of S. aureus isolates resistant to several classes of antimicrobial agents evaluated in this study.
Voxvoganan trihydrochloride (LTX-109) is a broad-spectrum, fast-acting bactericidal antimicrobial agent that binds to negatively charged membrane components on the bacterial cell wall, which leads to membrane disruption and cell lysis. Voxvoganan trihydrochloride is a first-in-class chemically synthesized, small peptide drug that is stable against protease degradation. Topical application of Voxvoganan trihydrochloride has a good safety profile and a low bioavailability. Voxvoganan trihydrochloride demonstrates good activity against Staphylococcus aureus strains that are susceptible and resistant to mupirocin.

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