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CAS No. : 1204572-55-3
MCE 国际站:BPAM344
产品活性:BPAM344 是红藻氨酸受体 (KAR) 亚基 GluK1b、GluK2a 和 GluK3a 的正变构调节剂 (PAM)。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:iGluR
In Vitro: BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics.
BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
相关产品:Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | 6-Methoxy-2-naphthoic acid | NMDA receptor modulator 4 | CIQ | Budipine | Glycine-15N,d2 | AMPA receptor modulator-3 | ZL006 | GluN2B-NMDAR antagonist-1 | Orphenadrine hydrochloride | AMPA receptor modulator-2 | (S)-Willardiine | Kynurenic acid-d5 | Fanapanel | N20C hydrochloride | Ifenprodil tartrate | GluN2B receptor modulator-1 | Decanoic acid-d2 | Coluracetam | Caroverine hydrochloride | L-Phenylalanine-d | Dynorphin A (1-10) (TFA) | L-Glutamic acid-d5 | JAMI1001A | Sepimostat | NMDA | CFM-2 | Cyclothiazide | JNJ-61432059 | DQP-1105 | L-Glutamic acid-13C5,15N,d5
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