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Traxoprodil

CAS No. : 134234-12-1

MCE 国际站：Traxoprodil

产品活性：Traxoprodil (CP101,606) 是一种有效的和选择性的 NMDA 拮抗剂，保护海马神经元的 IC₅₀ 值为10 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vivo: Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED₅₀ less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures.

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