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NCGC00247743

CAS No. : 1435192-04-3

MCE 国际站：NCGC00247743

产品活性：NCGC00247743 是一种组蛋白赖氨酸脱甲基酶 KDM4 抑制剂。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC₅₀s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Heterocyclic Compound Library  |  GSK2879552 dihydrochloride  |  KDM2B-IN-3  |  KDM4-IN-2  |  LSD1/ER-IN-1  |  GSK-J4 hydrochloride  |  Bomedemstat hydrochloride  |  LSD1-IN-18  |  KDM4-IN-4  |  (1S,2R)-Tranylcypromine hydrochloride  |  Pulrodemstat benzenesulfonate  |  GSK-J1 lithium salt  |  CPI-4203  |  JQKD82  |  Corin  |  Tranylcypromine hemisulfate  |  KDM2B-IN-4  |  (1R,2S)-NCD38 TFA  |  LSD1-IN-14  |  LSD1-IN-26  |  Helenalin acetate  |  KDM2B-IN-2  |  JHDM-IN-1  |  Seclidemstat  |  KDM5-IN-1  |  GSK-LSD1 dihydrochloride  |  LSD1-IN-21  |  Arborinine  |  KDM4-IN-3

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