MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

SR 146131

CAS No. : 221671-61-0

MCE 国际站：SR 146131

产品活性：SR 146131是一种有效，有口服活性，选择性的非多肽缩胆囊素1 (cholecystokinin 1)受体激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Cholecystokinin Receptor

In Vitro: SR 146131 inhibits in the binding of [¹²⁵I]-BH-CCK-8S to CCK1sites on 3T3-hCCK1 cell membranes with an IC₅₀ value of 0.56 ± 0.10 nM. At much higher concentrations, SR 146131 also inhibits the binding of radiolabeled CCK to CCK2sites in CHO-hCCK2 membranes with an IC₅₀ of 162 ± 27 nM. SR 146131 is a potent CCK1 agonist on several intracellular events linked to CCK1 receptor activation in various cell types: on [Ca²⁺]i release and IP1 formation, SR 146131 appears as a full CCK1 receptor agonist in the 3T3-hCCK1 cells, but a partial CCK1receptor agonist on MAPK activation and early gene expression in this cell line. SR 146131 also acts as a partial agonist in the two neuroblastoma cell lines.

In Vivo: SR 146131 completely inhibits gastric and gallbladder emptying in mice (ED₅₀ of 66 and 2.7 μg/kg p.o., respectively). SR 146131 dose dependently reduces food intake in fasted rats (from 0.1 mg/kg p.o.), in nonfasted rats in which food intake has been highly stimulated by the administration of neuropeptide Y (1–36) (from 0.3 mg/kg p.o.), in fasted gerbils (from 0.1 mg/kg p.o.), and in marmosets maintained on a restricted diet (from 3 mg/kg p.o.). SR 146131 (10 mg/kg p.o.) also increases the number of Fos-positive cells in the hypothalamic paraventricular nucleus of rats. Locomotor activity of mice is reduced by orally administered SR 146131 (from 0.3 mg/kg p.o.).

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Endocrinology Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Activators Library  |  (Rac)-Sograzepide  |  Nastorazepide  |  Proglumide hemicalcium  |  Lintitript  |  JNJ-26070109  |  L-365260  |  Devazepide  |  Tarazepide  |  A71623  |  Gastrazole  |  Pentagastrin  |  Lorglumide sodium salt  |  Loxiglumide  |  Dexloxiglumide  |  Mini Gastrin I, human  |  Gastrin I, human  |  Anthramycin  |  Gastrin/CCK antagonist 1  |  GI 181771  |  CHEMBL333994  |  CCK-B Receptor Antagonist 2  |  LY288513  |  Sincalide ammonium  |  CI-988  |  Tetragastrin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-11077

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。