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CAS No. : 1380088-03-8
MCE 国际站:KB SRC 4
产品活性:KB SRC 4 是一种有效的,高度选择性的 c-Src 抑制剂,Ki 和 Kd 值分别为 44 nM 和 86 nM,在浓度高达 125 μM 时,对 c-Abl 也无作用;KB SRC 4 具有抗肿瘤活性。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:Src
In Vitro: KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Angiogenesis-Related Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Tirbanibulin dihydrochloride | HIV-IN-6 | Bafetinib | Multi-kinase-IN-2 | PP2 | PP58 | ENMD-2076 Tartrate | Lck-IN-1 | Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH | Ponatinib hydrochloride | TL02-59 dihydrochloride | A-770041 | Masitinib | TX-1123 | Bosutinib hydrate | Ponatinib-d8 | 1-NM-PP1 | MNS | TG 100801 | Scutellarein | RR-SRC | LCB 03-0110 | TG 100572 | AMG-47a | AD57 | AD80 | Dasatinib monohydrate | Lck Inhibitor
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