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CU-CPT-8m

CAS No. : 125079-83-6

MCE 国际站：CU-CPT-8m

产品活性：CU-CPT-8m 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 67 nM。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: CU-CPT-8m is a specific TLR8 antagonist, with an IC₅₀ of 67±10 nM and negligible cytotoxicity. The K_d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC₅₀ of 90±10 nM, which is in good agreement with its IC₅₀ value determined in HEK-Blue TLR8 cells.

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