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CU-CPT9b

CAS No. : 2162962-69-6

MCE 国际站：CU-CPT9b

产品活性：CU-CPT9b 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 0.7 nM。CU-CPT9b 高亲和性结合 TLR8， K_d 值为 21 nM。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: CU-CPT9b is a specific TLR8 antagonist, with an IC₅₀ of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a K_d of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m.

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