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Ipragliflozin (L-Proline)

CAS No. : 951382-34-6

MCE 国际站：Ipragliflozin (L-Proline)

产品活性：Ipragliflozin (L-Proline) 是 SGLT2 高活性的，选择性抑制剂，IC₅₀ 为 2.8 nM，对 SGLT1/3/4/5/6 几乎无活性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：SGLT

In Vitro: Ipragliflozin (L-Proline) potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar ranges and exhibits stability against intestinal glucosidases.

In Vivo: Ipragliflozin (L-Proline) shows good pharmacokinetic properties following oral dosing, and dose-dependently increases urinary glucose excretion, which lasts for over 12 h in normal mice . Oral administration of ipragliflozin increases urinary glucose excretion in a dose-dependent manner, an effect which is significant at doses of 0.3 mg/kg or higher and lasts over 12 h. Single administration of ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance .

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