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CAS No. : 2448414-54-6
MCE 国际站:JMV 2959 hydrochloride
产品活性:JMV 2959 hydrochloride 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂,作用于 LLC-PK1 细胞,抑制 GHS-R1a,IC50 值为 32±3 nM。
研究领域:GPCR/G Protein
作用靶点:GHSR
In Vitro: JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM.
In Vivo: Intraperitoneal (i.p.) administration of Ghrelin (0.033, 0.1, and 0.33 mg/kg) does not alter the acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. Conversely, i.p. injection of JMV 2959 (1, 3, and 6 mg/kg), dose dependently decrease the ASR and increase PPI. Pretreatment with JMV 2959 at a dose with no effect on ASR or PPI per se, completely blocks Phencyclidine (PCP)-induced (2 mg/kg) deficits in PPI while pretreatment with the highest dose of Ghrelin does not potentiate or alter PPI responses of a sub-threshold dose of PCP (0.75 mg/kg).
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Endocrinology Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | K-(D-1-Nal)-FwLL-NH2 TFA | des-Gln14-Ghrelin | BMS-604992 free base | AZ-GHS-22 | Relamorelin acetate | Capromorelin Tartrate | Anamorelin hydrochloride | Ulimorelin | JMV 2959 | PF-6870961 | Macimorelin | Human growth hormone-releasing factor | Ibutamoren Mesylate | TC-G-1008 | L-692429 | PF-5190457 | GSK1614343 | L-692585 | YIL781 | AZP-531 | GHRF, bovine | des-Gln14-Ghrelin TFA
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