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CAS No. : 136-16-3
MCE 国际站:Oxythiamine
产品活性:Oxythiamine (Hydroxythiamin) 是一种抗代谢物的类似物,可以抑制核糖的非氧化合成,诱导细胞凋亡 (apoptosis) 。Oxythiamine 是一种硫胺素拮抗剂,可抑制转酮醇酶 (transketolase) (TK)。Oxythiamine 抑制癌细胞凋亡 (apoptosis) 并抑制细胞增殖。
研究领域:Apoptosis | Metabolic Enzyme/Protease
作用靶点:Apoptosis | Endogenous Metabolite
In Vitro: Oxythiamine (0-40 μM, 2 days) inhibits cell viability of MIA PaCa-2 cells (IC50: 14.95 μM).
Oxythiamine chloride hydrochloride (0-500 μM, 48 h) suppresses expression of 14-3-3 protein beta/alpha in MIA PaCa-2 cells.
Oxythiamine (0.1-100 μM, 6-48 h) inhibits A549 cell proliferation.
Oxythiamine (0.1-100 μM, 24 h) induces A549 cell apoptosis.
Oxythiamine (0-20 μM) inhibits the invasion and migration (IC50: 8.75 μM) of Lewis lung carcinoma (LLC) cells.
In Vivo: Oxythiamine (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice.
Oxythiamine (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells.
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