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CAS No. : 53956-04-0
MCE 国际站:Ammonium glycyrrhizinate
产品活性:Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) 具有抗炎、抗过敏、抗胃溃疡、抗肝炎等药理活性。
研究领域:Others
作用靶点:Others
结构分类:萜类 | 三萜
来源:植物 | 豆科 | 甘草
In Vivo: The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30mg/kg) administration. Pretreatment with MAG (10 and 30mg/kg) efficiently reduces the production of TNF-?? and IL-1??. MAG (10, 30mg/kg) significantly decreases NF-??B p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces I??B-?? protein expression compared with the control group, whereas MAG (10 and 30mg/kg) significantly increased I??B-?? expression, compared with the LPS group.
Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries.
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货号: HY-76225
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