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CAS No. : 136656-07-0
MCE 国际站:Timosaponin BII
产品活性:Timosaponin BII (Prototimosaponin A III) 是在知母根茎中发现的一种甾体皂苷。Timosaponin BII 具有神经保护、抗炎和抗氧化活性。
研究领域:Neuronal Signaling
作用靶点:Amyloid-β
结构分类:甾体类 | 结构分类
来源:植物 | 百合科 | 知母
In Vitro: Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells.
In Vivo: Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.
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货号: HY-N0812
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