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CAS No. : 1876450-21-3
MCE 国际站:MM 07
产品活性:MM 07 是一种有偏倚性的 apelin 受体 (apelin receptor) 激动剂,在 CHO-K 细胞中的 KD 值为 300 nM,在人心脏中的 KD 值为 172 nM。
研究领域:GPCR/G Protein
作用靶点:Apelin Receptor (APJ)
In Vitro: MM 07 competes with nanomolar affinities for binding of [Glp65,Nle75,Tyr77] [125I]apelin-13 to human apelin receptors in CHO-K1 cells (KD, 300 nM) and human heart (KD, 172 nM, n=3).
In Vivo: MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr1]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr1]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr1]apelin 13 and MM 07 increases peak velocity above basal levels.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Peptidomimetic Library | Covalent Screening Library | Macrocyclic Compound Library | Anti-Cardiovascular Disease Compound Library | Targeted Diversity Library | Peptide Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | APJ receptor agonist 1 | CMF019 | Apelin-13 TFA | APJ receptor agonist 4 | [Pyr1]-Apelin-13 | ELA-21 (human) | ELA-11(human) TFA | APJ receptor agonist 6 | ELA-32(human) TFA | NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) | ML233 | Elabela(19-32) | APJ receptor agonist 5 | NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) | ML221 | Azelaprag | (Ala13)-Apelin-13 | AM-8123 | Apelin agonist 1 | MM 54 | APJ receptor agonist 3
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