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CAS No. : 159182-43-1
MCE 国际站:L755507
产品活性:L755507 是一个有效的, 选择性强的 β3-AR 激动剂, 其 IC50 值为 35 nM。L755507 增强 CRISPR/Cas9 切口酶系统中的同源定向修复 (HDR) 介导的基因组编辑。
研究领域:GPCR/G Protein | Neuronal Signaling | Cell Cycle/DNA Damage
作用靶点:Adrenergic Receptor | CRISPR/Cas9
In Vitro: L755507 causes a robust concentration-dependent increase in cAMP accumulation (pEC50 values of 8.5 and 12.3, respectively). Maximal cAMP accumulation with zinterol and L755507 is increased after pretreatment with pertussis toxin. In contrast to cAMP, zinterol, L755507 and L748337 increase phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with very high potency (pEC50 values of 10.9, 11.7 and 11.6). L755507 and Scr7 do not reduce cell viability significantly. Scr7 does not affect cell cycle distribution in a range of 10 to 200 μM. L755507 significantly decreases the proportion of cells in the G2/M phase at 10 μM or 40 μM and increases the S-phase cells at 10 μM compare with the DMSO-treated cells.
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货号: HY-19334
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