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CAS No. : 216167-82-7
MCE 国际站:Succinobucol
产品活性:Succinobucol 是一种酚类抗氧化剂,具有抗炎、抗血小板聚集的作用。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Reactive Oxygen Species
In Vitro: Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation in rabbit whole blood. Succinobucol also causes a significant reduction in whole blood aggregation in response to ADP. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO. Succinobucol significantly prevents 3-NP-induced loss of SH-SY5Y cell viability, generation of reactive oxygen species, and decrease of ΔΨm. Succinobucol does not protect against 3-NP-induced inhibition of mitochondrial complex II activity, pointing to the mitigation of secondary events resultant from mitochondrial complex II inhibition. Succinobucol significantly increases (50 %) the levels of GSH in SH-SY5Y cells, which is paralleled by significant increases in glutamate cysteine ligase messenger RNA (mRNA) expression and activity. Succinobucol effectively exhibits superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Succinobucol also shows inhibitory effect on VCAM-1 expression in 4T1 cells and cell-cell binding of RAW 264.7 to 4T1 cancer cells.
In Vivo: Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP, but the blood removed 15 minutes after the final injection of succinobucol shows significantly less aggregation in response to collagen at both 5 µg/mL and 20 µg/mL in rats. Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules in lung metastatic breast cancer mice.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Anti-COVID-19 Compound Library | Pyroptosis Compound Library | Anti-Breast Cancer Compound Library | Mitochondria-Targeted Compound Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | D-α-Hydroxyglutaric acid disodium | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Anticancer agent 120 | 7-Hydroxy-4-methyl-2(1H)-quinolone | N-tert-Butyl-α-phenylnitrone-d14 | BDP 581/591 NHS ester | Cysteamine-d4 hydrochloride | L-Ascorbic acid sodium salt | Manganese(salen) chloride | Hydroxyphenyl Fluorescein | Glucosamine sulfate | Maresin 1 | Berberine | 1,3-Dicaffeoylquinic acid | Ciprofloxacin | Echinocystic acid | Lacto-N-fucopentaose I | Nisoldipine-d6 | Arg-Tyr | HKPerox-2 | 3-Indolepropionic acid | 2-Methoxyestradiol-13C,d3 | Albendazole | QD394 | AKBA | Cedrin | Deferoxamine | Ellagic acid | Acetylcysteine-d3 | N-Acetyl-D-cysteine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-14937
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