MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BPR1J-097 Hydrochloride

CAS No. :

MCE 国际站：BPR1J-097 Hydrochloride

产品活性：BPR1J-097 Hydrochloride 是一个新型且强效的 FLT3 抑制剂，其 IC₅₀ 值为 11 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FLT3

In Vitro: BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC₅₀ of 11nM. Phosphorylation of all FLT3-WT, FLT3-IDT, and FLT3-D835Y are inhibited by BPR1J-097 Hydrochloride at a concentration as low as 10 nM. BPR1J-097 Hydrochloride suppresses the phosphorylation of FLT3 and STAT5 in a dose-dependent manner. The IC₅₀ values of BPR1J-097 Hydrochloride on MOLM-13 and MV4-11 cells are 21±7 and 46±14 nM, respectively. The emergence of active caspase-3 is observed in MOLM-13 cells treated with BPR1J-097 Hydrochloride at 10 nM. The effect of BPR1J-097 Hydrochloride seems to be weaker in MV4-11 cells as caspase-3 is not evident until 100 nM of BPR1J-097 Hydrochloride is applied to treat cells.

In Vivo: After i.v. administration of mice with BPR1J-097 Hydrochloride at two cycles of 10 or 25 mg/kg, a clear dose-dependent anti-tumour effect is observed. Tumours in mice treated with BPR1J-097 Hydrochloride (25 mg/kg per day) stop growing. BPR1J-097 Hydrochloride (25 mg/kg) shows a significant tumour shrinkage effect on the subcutaneously growing MOLM-13 tumours in a size of >2000 mm³. BPR1J-097 Hydrochloride (10 and 25 mg/kg) also produces a dose-dependent growth reduction and shrinkage of another model using MV4-11 cells. It is noted that a prolonged disappearance of MV4-11 tumours is observed in mice treated with BPR1J-097 Hydrochloride at 25 mg/kg. There is little (3%) or no body weight loss of BPR1J-097 Hydrochloride-treated nude mice during the observation periods in these in vivo studies.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  JNJ-47117096 hydrochloride  |  Sorafenib-d₄  |  AT9283  |  (E/Z)-Zotiraciclib  |  AKN-028 acetate  |  Sorafenib Tosylate  |  BPR1K871  |  ENMD-2076 Tartrate  |  AZD2932  |  Hypothemycin  |  UNC2025 hydrochloride  |  Tandutinib  |  UNC4203  |  3-Hydroxy Midostaurin  |  Cabozantinib  |  LBW242  |  MAX-40279 hemifumarate  |  JAK2-IN-7  |  TAK-659 hydrochloride  |  Gilteritinib-d₈  |  BSc5371  |  FLT3/CDK4-IN-1  |  Tyrphostin AG1296  |  FLT3-IN-4  |  FLT3-IN-18  |  Cabozantinib-d₄  |  Gilteritinib hemifumarate  |  Tuspetinib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-13537A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。