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CAS No. : 125316-60-1
MCE 国际站:CD437
产品活性:CD437 是一个选择性视黄酸受体 (Retinoic Acid Receptor γ (RARγ)) 激动剂。
研究领域:Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Autophagy
作用靶点:RAR/RXR | Autophagy
In Vitro: CD437 is a selective RARγ agonist. Growth inhibition by CD437 in these lung cancer cell lines is apparent after 2 days of treatment with 10 μM CD437. Dose-response experiments demonstrate that CD437 reduces the numbers of H460, SK-MES-1, A549, and H292 cells with 50% inhibitory values of approximately 0.5, 0.4, 3, and 0.85 μM, respectively.
Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity.
In Vivo: Tumors in CD437-treated mice stop growing, an effect that becomes already statistically significant (P<0.01) at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroma edge in CD437-treated tumors.
相关产品:Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Anti-Lung Cancer Compound Library | Transcription Factor-Targeted Library | Targeted Diversity Library | Human Metabolite Library | Nuclear Receptor Compound Library | Highly Selective Activators Library | Tazarotene-d8 | Retinoic acid | LG101506 | CD2314 | BMS453 | ATRA-biotin | BPA-B9 | AGN 193109 | Magnolol | AGN 194078 | Tazarotene | (-)-Talarozole | Bigelovin | Ch55 | AGN-195183 | BMS-195614 | Fenretinide | LG-100064 | AC-261066 | Liarozole | BMS641 | Tamibarotene | PA452 | Tarenflurbil | 9-cis-Retinoic acid-d5 | Fluorobexarotene | Retinoic acid-d6 | Adapalene | Oxybenzone | CD2665
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货号: HY-100532
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