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(E)-Cardamonin

CAS No. : 19309-14-9

MCE 国际站：(E)-Cardamonin

产品活性：(E)-Cardamonin ((E)-Cardamomin) 是新颖的hTRPA1阳离子通道拮抗剂，IC₅₀值为454 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Apoptosis

作用靶点：TRP Channel  |  Apoptosis

结构分类：黄酮类  |  查耳酮  |  酚类  |  多酚类

来源：植物  |  姜科  |  草豆蔻

In Vitro: (E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC₅₀=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.

In Vivo: (E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.

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