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CAS No. : 87096-84-2
MCE 国际站:Neuromedin B
产品活性:Neuromedin B 是一种含10个氨基酸的神经肽,属于蛙肽家族,为铃蟾肽相关肽。
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:其他类 | 结构分类
In Vitro: Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB).
In Vivo: Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.
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