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CAS No. : 6211-32-1
MCE 国际站:Rauwolscine hydrochloride
产品活性:Rauwolscine hydrochloride是高效,选择性的 α2 adrenergic 受体拮抗剂,Ki 值为12 nM。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Adrenergic Receptor
结构分类:生物碱 | 吲哚类生物碱
来源:植物 | 其他科
In Vitro: [3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM). Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .
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货号: HY-12710A
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