MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 6138-41-6
MCE 国际站:Trigonelline chloride
产品活性:Trigonelline chloride 是一种大量存在于益母草中并且具有潜在抗糖尿病活性的生物碱。Trigonelline chloride 具有抗 HSV-1,抗菌和抗真菌活性。
研究领域:Anti-infection | Metabolic Enzyme/Protease
作用靶点:HSV | Bacterial | Fungal | Endogenous Metabolite
结构分类:生物碱 | 吡啶类生物碱
来源:植物 | 菊科 | 宿根莴苣 | 植物 | 唇形科
In Vitro: It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H2O2 can induce the necrosis and apoptosis along with H2O2.
In Vivo: Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Antiviral Compound Library | Anti-Aging Compound Library | Anti-diabetic Compound Library | Oxygen Sensing Compound Library | Antifungal Compound Library | Antibacterial Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Alkaloids Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Antiviral Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | D-Valine-d8 | Antifungal agent 26 | D-α-Hydroxyglutaric acid disodium | Myricetin 3-O-α-L-arabinopyranoside | Nicotinamide N-oxide | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Nebacumab | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Gepotidacin | Amycolatopsin A | PC945 | Palitantin | Antibiotic A-33853 | Estradiol hemihydrate | Sulbactam-d2 sodium | Adrenaline sulfate | Oleic acid-13C | Dextranase | Antimicrobial agent-5 | NBTIs-IN-4 | H2S Donor 5a | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Chitin synthase inhibitor 11 | Methylmalonic acid | Antitubercular agent-13 | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-N0415
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。