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Tectorigenin

CAS No. : 548-77-6

MCE 国际站：Tectorigenin

产品活性：Tectorigenin 是一种植物异黄酮，最初是从葛根汤干燥的花中分离出来的。

研究领域：Others

作用靶点：Others

结构分类：黄酮类  |  异黄酮

来源：植物  |  豆科  |  野葛

In Vitro: Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Palmitic acid (PA)-stimulated ROS production is abolished by treatment with Tectorigenin for HUVECs in a dose-dependent manner (0.1, 1, 10 μM). Treatment with Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. Tectorigenin treatment also effectively inhibits PA-augmented TNF-α and IL-6 production in a concentration dependent manner. The number of viable HepG2 cells treated by Tectorigenin decreases in a concentration- and time-dependent manner. When HepG2 cells are treated with Tectorigenin at 5, 10 and 20 mg/L for 24 h, the viability rate is 91%, 79% and 62%, respectively.

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