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Monensin sodium salt

CAS No. : 22373-78-0

MCE 国际站：Monensin sodium salt

产品活性：Monensin sodium salt 是由肉桂链霉菌 (Streptomyces cinnamonensis) 分泌的抗生素。Monensin sodium salt 是一种介导 Na⁺/H⁺ 交换的离子载体。Monensin sodium salt 引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。

研究领域：Anti-infection  |  Membrane Transporter/Ion Channel

作用靶点：Bacterial  |  Antibiotic  |  Na+/H+ Exchanger (NHE)  |  Parasite

结构分类：抗生素  |  疾病研究  |  抗菌  |  抗生素  |  其他类  |  抗生素  |  种植业研究  |  结构分类

In Vitro: Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Untreated cells display 2.5% apoptosis; 48 hours treatment with 1 μM Monensin sodium salt shows 4.5% apoptosis whereas 5 μM Monensin sodium salt for 48 hours induces a greater apoptotic response (16.4%). Pretreatment with either 1 or 5 μM Monensin sodium salt for 24 hours followed by 10 μM erlotinib treatment for another 24 hours results in a marked increases in apoptotic events (14.6% and 38.7%, respectively) when compare with either Monensin sodium salt or erlotinib treatments alone. Combination of 5 μM Monensin sodium salt with 10 μM erlotinib shows the highest percentage of apoptosis (38.7%).

In Vivo: Although the numbers of tumors do not change substantially, a significant (P=0.0144) reduction in the average size of lesions is observed in Monensin sodium salt-treated Apc^+/Min mice when compare with control animals (mean 0.199 mm² vs. 0.299 mm²). The total tumor area estimated in one animal is decreased in individuals receiving Monensin sodium salt (mean 10.16 mm² vs. 16.46 mm²; P=0.0125). Monensin sodium salt treatment increases the numbers of apoptotic cells and cells expressing the p21 cell-cycle inhibitor at the surface area of the neoplastic outgrowths. No changes in the cell proliferation, differentiation, and tissue architecture in the healthy parts of mucosa are noted after exposure to Monensin sodium salt.

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