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Josamycin

CAS No. : 16846-24-5

MCE 国际站：Josamycin

产品活性：Josamycin (EN-141) 是一种大环内酯类抗生素，对多种病原体， 比如细菌 (bacteria) 具有抗菌活性。 Josamycin (EN-141) 对核糖体的解离常数 K_d 为 5.5 nM。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

结构分类：抗生素  |  疾病研究  |  抗菌  |  抗生素  |  大环内脂类  |  结构分类

In Vitro: Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin.

In Vivo: Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.

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货号: HY-B1920

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