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Gentiopicroside

CAS No. : 20831-76-9

MCE 国际站：Gentiopicroside

产品活性：Gentiopicroside 是一种天然的环烯醚萜苷，能够抑制 P450 的活性，对 CYP2A6 的 IC₅₀ 和 K_i 值分别为 61 µM 和 22.8 µM；Gentiopicroside 具有抗炎和抗氧化活性。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Cytochrome P450  |  HCV

结构分类：萜类  |  环烯醚萜  |  结构分类

来源：植物  |  龙胆科  |  龙胆

In Vitro: Gentiopicroside inhibits P450 activity, with an IC₅₀ and a K_i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC₅₀ of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption.

In Vivo: Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.

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