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L-Cysteinesulfinic acid

CAS No. : 1115-65-7

MCE 国际站：L-Cysteinesulfinic acid

产品活性：L-Cysteinesulfinic acid 是一种有效的代谢型谷氨酸受体 (mGluRs) 激动剂，作用于mGluR1，mGluR5，mGluR2，mGluR4，mGluR6 和 mGluR8，pEC₅₀ 分别为 3.92，4.6，3.9，2.7，4.0，和 3.94。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：mGluR  |  Endogenous Metabolite

结构分类：酮、醛、酸

In Vitro: L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC₅₀ of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increasesin cell firing.

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