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Glycocholic acid

CAS No. : 475-31-0

MCE 国际站：Glycocholic acid

产品活性：Glycocholic acid 是具有抗肿瘤活性的胆汁酸，可靶向作用于耐药泵和非耐药泵通路。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：甾体类  |  结构分类

In Vitro: Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.

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