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CAS No. : 480-10-4
MCE 国际站:Astragalin
产品活性:Astragalin (Astragaline) 是一种具有抗炎、抗氧化、抗癌、抑菌活性的黄酮类化合物。Astragalin 抑制癌细胞增殖和迁移,诱导细胞凋亡 (apoptosis)。Astragalin 具有口服活性,具有保护神经和心脏,抵抗骨质疏松的作用。
研究领域:Apoptosis | NF-κB
作用靶点:Apoptosis | NF-κB
结构分类:黄酮类 | 黄酮醇 | 酚类 | 多酚类 | 结构分类
来源:植物 | 檀香科 | 百蕊草
In Vitro: Astragalin (0-80 μg/mL; 24 h, 48 h, 72 h) inhibits cancer cells viability and migration at 20, 40, 80 μM, and shows no cytotoxicity to normal human colon epithelial cell lines NCM460.
Astragalin (80 μg/mL; 4 h, 8 h) interrupts the NF-κB signaling pathway and inhibits NF-κB P65 transcriptional activity in HCT116 cells stimulated by TNF-α.
Astragalin (20, 40, 80 μg/mL; 48 h) induces HCT116 cells apoptosis and arrests cell cycle at G0/G1 phase.
Astragalin (20, 40, 80 μg/mL; 48 h) increases the level of apoptin in HCT116 and decreases the level of anti-apoptotic proteins in a dose-dependent manner.
In Vivo: Astragalin (25, 50, and 75 mg/kg; p.o.; once every two days; 25 d) reduces the tumor volumes, tumor weight and tumor formation rates and decreases expression of p-NFκB and p-iκκα in nude mouse model with human colon cancer.
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货号: HY-N0015
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