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CAS No. : 18642-23-4
MCE 国际站:Psoralidin
产品活性:Psoralidin 是 COX-2 和 5-LOX 的双重抑制剂。具有抗癌,抗菌和抗炎作用。Psoralidin 显著下调 NOTCH1 信号传导。Psoralidin 还极大地诱导 ROS 产生。
研究领域:Immunology/Inflammation | Metabolic Enzyme/Protease | Neuronal Signaling | Stem Cell/Wnt | NF-κB | Anti-infection
作用靶点:COX | Lipoxygenase | Notch | Reactive Oxygen Species | Bacterial
结构分类:酚类 | 多酚类 | 结构分类
来源:植物 | 豆科 | 补骨脂
In Vitro: Three breast cancer cell (BCC)populations (ALDH- cells, ALDH+ cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC50s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin.
Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH- cells, ALDH+ cells, and commercial BCSCs.
Psoralidin treatment also downregulates NOTCH1 expression in both ALDH- and ALDH+ cells.
In Vivo: Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse.
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货号: HY-N0232
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