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Isosteviol

CAS No. : 27975-19-5

MCE 国际站：Isosteviol

产品活性：Isosteviol ((-)-Isosteviol) 是一种甜菊糖苷衍生物，是甜菊糖苷通过酸催化水解产生的。Isosteviol 抑制 DNA 聚合酶和 DNA 拓扑异构酶，并具有抗菌，抗癌和抗结核作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage

作用靶点：Reactive Oxygen Species  |  Topoisomerase

结构分类：萜类  |  二萜

来源：植物  |  其他科

In Vitro: Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10^-8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10^-2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10^-8 M vasopressin.
The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca²⁺]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca ²⁺]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present.
Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.

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