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Tetrabenazine-d₆

CAS No. : 1392826-25-3

MCE 国际站：Tetrabenazine-d₆

产品活性：Tetrabenazine-d₆ (Deutetrabenazine) 是 Tetrabenazine (HY-B0590) 的氘代物，是全球首个批准的氘代物，可用于亨廷顿舞蹈症及其他多动运动障碍的研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Monoamine Transporter

In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy and tolerability, and increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall and liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses and better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites and improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds and are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs in previous studies.

相关产品：Tetrabenazine Racemate  |  FFN511  |  Cavα2δ1&NET-IN-1  |  Nisoxetine  |  Tetrabenazine Metabolite  |  Trans (2,3)-Dihydrotetrabenazine  |  Cavα2δ1&NET-IN-2  |  (+)-Tetrabenazine-d₆  |  hENT4-IN-1  |  Reserpine-d₉  |  GZ-793A  |  Radafaxine hydrochloride  |  Reserpine  |  Valbenazine  |  FFN200 dihydrochloride  |  Tetrabenazine mesylate  |  Vanilpyruvic acid  |  VMAT2-IN-2 tosylate  |  13-Hydroxyisobakuchiol  |  Pseudoisocyanine iodide

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货号: HY-B0590S

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