MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 12650-69-0
MCE 国际站:Mupirocin
产品活性:Mupirocin (BRL-4910A, Pseudomonic acid) 可从 Pseudomonas fluorescens 中分离得到,是一种有口服活性的抗生素。Mupirocin 通过可逆地抑制异亮氨酸转移 RNA,从而抑制细菌蛋白和 RNA 的合成而发挥抗菌作用。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 其他类 | 结构分类
In Vitro: Mupirocin (BRL-4910A, Pseudomonic acid) (0-100 μM; 48 h) shows antibacterial effect against staphylococci, streptococci and certain gram-negative bacteria, with MIC values range from 0.06-0.25 μg/mL (MIC50 =0.12 μg/mL, MIC90 =0.25 μg/mL).
Mupirocin is highly bound (95% bound) to human serum protein, thus results in activity inhibition in the presence of human serum.
Mupirocin apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.
Mupirocin (2% ointment) reduces pro-inflammatory cytokines IL-1β and IL-17 level, decreases tumor necrosis factor-alpha (TNF-α) expression, and increases the leavel of vascular endothelial growth factor (VEGF).
Mupirocin inhibits MS (S. epidermidis ATCC 12228), MR (S. epidermidis (Se56-99)), and VIR (S. epidermidis (Se43-98)) with MICs of 0.25, 1.26, 1.59 mg/L.
Note: MIC, the minimum inhibition concentration.
In Vivo: MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.
Mupirocin (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment.
Mupirocin (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice.
Mupirocin (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis.
相关产品:Covalent Screening Library Plus | Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Natural Product Library | FDA-Approved Drug Library | Antiviral Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Antibacterial Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Pyroptosis Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Anti-Pancreatic Cancer Compound Library | Microbial Metabolite Library | Rare Diseases Drug Library | Children’s Drug Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Myricetin 3-O-α-L-arabinopyranoside | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Nebacumab | Doxorubicin-13C,d3 TFA | Gepotidacin | Amycolatopsin A | Antibiotic A-33853 | Estradiol hemihydrate | Sulbactam-d2 sodium | Antimicrobial agent-5 | NBTIs-IN-4 | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Antitubercular agent-13 | Toyocamycin | Lenampicillin hydrochloride | Hispolon | PC58538 | SPR206 acetate | Caracemide | Antimicrobial agent-10 | Doxycycline calcium | Antibacterial agent 138 | Staurosporine | Dihydrostreptomycin sulfate | Ciclopirox olamine | Rubropunctamine | Topoisomerase IV inhibitor 2 | Psoracorylifol C
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-B0958
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。