MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 57378-72-0
MCE 国际站:4,5-Dicaffeoylquinic acid
产品活性:4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种抗氧化剂,可从 Gynura divaricata 和 Laggera alata 中分离获得。4,5-Dicaffeoylquinic acid 能减少 2 型糖尿病小鼠胰岛细胞凋亡 (apoptosis),改善胰腺功能,对酵母 α-葡萄糖苷酶 (α-glucosidase) 有明显的抑制活性。4,5-Dicaffeoylquinic acid 通过阻滞细胞周期来抑制前列腺癌细胞增殖。4,5-Dicaffeoylquinic acid 还具有抗凋亡、抗损伤和抗乙型肝炎病毒 (HBV)的作用。
研究领域:Anti-infection | Metabolic Enzyme/Protease | Apoptosis
作用靶点:HBV | Endogenous Metabolite | Apoptosis | Glucosidase
结构分类:酚类 | 多酚类 | 酮、醛、酸
来源:植物 | 豆科 | 维吉豆状鲍迪豆 | 植物 | 菊科
In Vitro: 4,5-Dicaffeoylquinic acid (0.1~100 µM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2.
4,5-Dicaffeoylquinic acid (1~100 µg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 µg/mL.
4,5-Dicaffeoylquinic acid (1~100 µg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 µg/mL on expressions of HBsAg and HBeAg, respectively.
In Vivo: 4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Antiviral Compound Library | Antioxidant Compound Library | Anti-diabetic Compound Library | Medicine Food Homology Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Food-Sourced Compound Library | Antiviral Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | D-Valine-d8 | SY-5609 | D-α-Hydroxyglutaric acid disodium | BRD4 Inhibitor-18 | Nicotinamide N-oxide | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | AAPK-25 | Dutasteride-13C6 | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Anticancer agent 120 | Abacavir sulfate | Methylmalonic acid | Meloxicam-d3-1 | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Thailanstatin D | SB-218078 | Toyocamycin | Sorafenib-d4 | Sphingomyelin | (-)-Jasmonoyl-L-isoleucine | Busulfan | PTC-028
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-N0058
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。