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Chicoric acid

CAS No. : 6537-80-0

MCE 国际站：Chicoric acid

产品活性：Chicoric acid (Cichoric acid) 是一种口服有效的二咖啡基酒石酸，可以诱导活性氧 (ROS) 的产生。Chicoric acid 抑制细胞活力，并通过 ROS 介导的 PI3K/Akt 和 MAPK 信号通路诱导 3T3-L1 前脂肪细胞中的线粒体依赖性细胞凋亡。Chicoric acid 增加葡萄糖摄取，改善胰岛素抵抗，并减轻氨基葡萄糖诱导的炎症。Chicoric acid 具有抗糖尿病和抗氧化、抗炎作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

结构分类：苯丙素类  |  其他苯丙素类  |  酚类  |  多酚类

来源：植物  |  其他科

In Vitro: Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability.
Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway.
Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt.
Chicoric acid (25, 50, 100 µM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells.
Chicoric acid (100 µM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells.
Chicoric acid (100 µM) has no effects on HepG2 cell viability.

In Vivo: Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days).

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