MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ginsenoside Rf

CAS No. : 52286-58-5

MCE 国际站：Ginsenoside Rf

产品活性：Ginsenoside Rf 是人参根的一种微量成分。 Ginsenoside Rf 抑制 N 型 Ca²⁺ 通道。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：Calcium Channel  |  Endogenous Metabolite

结构分类：萜类  |  三萜

来源：植物  |  五加科  |  人参

In Vitro: Ginsenoside Rf is a saponin, which is present in only trace amounts within ginseng. At saturating concentrations, Ginsenoside Rf rapidly and reversibly inhibits N-type, and other high-threshold, Ca²⁺ channels in rat sensory neurons to the same degree as a maximal dose of opioids. The effect is dose-dependent (half-maximal inhibition: 40 μM) and it is virtually eliminated by pretreatment of the neurons with pertussis toxin, an inhibitor of G(o) and Gi GTP-binding proteins. Ginsenoside Rf also inhibits Ca²⁺ channels in the hybrid F-11 cell line.

In Vivo: Since inhibition of Ca²⁺ channels in sensory neurons contributes to antinociception by opioids, analgesic actions of Ginsenoside Rf are tested. Dose-dependent antinociception is found by systemic administration of Ginsenoside Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED₅₀ is 56±9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED₅₀ is 129±32 mg/kg.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Glycoside Compound Library  |  Medicine Food Homology Compound Library  |  Terpenoids Library  |  Traditional Chinese Medicine Active Compound Library  |  Neuroprotective Compound Library  |  Food-Sourced Compound Library   |  Anti-Cancer Natural Product Library  |  Plant-Sourced Natural Product Library  |  Calcium Channel Blocker Library  |  Human Metabolite Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  D-Valine-d₈  |  D-α-Hydroxyglutaric acid disodium  |  Nicotinamide N-oxide  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ TFA  |  Palitantin  |  Estradiol hemihydrate  |  Benidipine hydrochloride  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Methylmalonic acid  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine  |  Isotachysterol 3  |  Octanoic acid-d₂  |  Vardenafil-d₅  |  N-Acetyllactosamine  |  D-Arabitol-¹³C  |  Imidazole  |  IAA65  |  L-Tartaric acid diammonium  |  i-Inositol  |  Tryptophol  |  L-Aspartic acid  |  Ranolazine-d₈ dihydrochloride  |  Indolelactic acid

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-N0601

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。